Point-of-Care Early Diagnostic Test for Preeclampsia (Duke University, Makerere University)

The goal of this project is to develop a safe, inexpensive, and reliable self-diagnostic tool for the early detection of preeclampsia that can be accessible to pregnant women in low-resource settings, thereby reducing the detrimental health impacts of undiagnosed preeclampsia and eclampsia. The earliest indicators for developing preeclampsia are dramatically increased levels of biomarkers activin A and inhibin A in a woman’s urine. The self-diagnostic tool will be a urine strip created by adapting lateral flow assay technology to detect the levels of activin A and inhibin A in the urine of pregnant women. The test will inform the woman if she is developing preeclampsia and needs to seek medical care before her symptoms become severe and endanger the life of her and her unborn child.